有一位病患在maxillary central與lateral incisors之間有non-3-wall intrabony defect，此兩顆牙齒間的interdental space width＞2 mm，而該患者堅持只進行一次手術，如果要進行GTR的治療，以Cortelini & Tonitti（2005）所提出的GTR evidence-based operative decision making流程，下列何種術式與醫材組合最適當？
Modified papilla preservation technique + bone graft + bioresorbable membrane
Modified papilla preservation technique + bone graft + non-bioresorbable membrane
Modified papilla preservation technique + EMD（enamel matrix protein, Emdogain）
Simplified papilla preservation technique + bone graft + bioresorbable membrane
