當粒線體呼吸（mitochondrial respiration）被抑制時，也會造成嘧啶（pyrimidine）重新合成路徑（de novo synthesis）之抑制，此現象是影響下列何種酵素所造成？
carbamoyl phosphate synthetase
aspartate transcarbamoylase
dihydroorotate dehydrogenase
orotidine 5'-mono-phosphate decarboxylase
