14歲男童於橋腦(pons)處有一經病理切片診斷為diffuse glioma, WHO grade II。針對brain stem glioma往往具有某特殊的基因變化,現已被歸屬成另外單獨類別之glioma,此特殊的基因變化是:
ATRX loss
H3.1 or H3.3 K27M mutation
MGMT hypermethylation
1p/19q co-deletion