下列有關酵素異常的敘述，何者最可能導致痛風（gout）的發生？
缺乏citrate synthase
5-phosphoribosyl-1-pyrophosphate synthetase活性降低
hypoxanthine-guanine phosphoribosyltransferase活性降低
glucose 6-phosphatase表現量上升
